Skip to main content
. Author manuscript; available in PMC: 2010 Aug 7.
Published in final edited form as: Cell Stem Cell. 2009 Aug 7;5(2):204–213. doi: 10.1016/j.stem.2009.06.002

TABLE 1.

Signaling proteins with more phosphorylation site identifications in undifferentiated hESCs than in hESC derivatives*

Proteins participating in Receptor Tyrosine Kinase signaling
Receptors,
Growth factors		 Kinases Phospholipases Adaptors Other
AREG, KDR,
IGF2R, EPHA1		 LCK, NEK4,
MAPK6, MAPK7,
FRAP1 (mTOR),
PI3KC3, PI3KR4,
DBF4,
CDC42BPA,
CRKL, MINK1,
KIAA1804
(MLK4), CDKL5,
EIF2AK1, CRKRS		 PLCG1, PLCG2,
PLCH1		 SHC1, GAB1,
NCK2, KIAA1303
(RAPTOR),
CNKSR1,
CNKSR2, ABI2,
CDC37L1,
PLEKHA1		 PPAP2B,
EPS15L1, TRAF4,
APC, CDH17,
IGFBP2,
RAPGEF1,
TRIP10, TSC1,
WDR62, NUMB
Signal transduction pathways and member proteins
MAPK: JNK**, ERK CRKL, MINK1, KIAA1804 (MLK4), TRAF4, TRIP10, WDR62,
CNKSR1, DBF4, CDC42BPA, RAPGEF1, PLCG1, SHC1, PLCG2, GAB1,
LCK, MAPK6, MAPK7, NEK4, NCK2
PI3K/AKT/mTOR FRAP1 (mTOR), TSC1, GAB1, PIK3C3, PLCG2, PIK3R4, KIAA1303
(RAPTOR), ANRT (HIF-1β)
*

Official symbols of the proteins, some of which are followed by synonyms in parenthesis, are used in this table.

**

Symbols in bold text represent proteins that are relatively specific to JNK signaling.