Figure 4. REV-ERBα controls Cyp7a1 transcription and bile acid accumulation.

(A) Temporal Cyp7a1 mRNA accumulation in the livers of WT, Rev-KO, and (B) TgRev mice. The data represent the mean±SEM (n = 4–6). (C) Primary and secondary bile acid levels in gallbladders from WT and Rev-KO mice. Data represent the mean±SEM (n = 6). p-Values: *, <0.05; **, <0.005.