Skip to main content
. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Nat Cell Biol. 2009 Jun 7;11(7):909–913. doi: 10.1038/ncb1901

Figure 4. Induction of filamentous tau pathology in non-transgenic C57BL/6 mice injected with brain extract from mice transgenic for human P301S tau.

Figure 4

Gallyas-Braak silver staining and immunostaining with phosphorylation-dependent anti-tau antibody AT8, murine tau-specific antibody MT1 and human tau-specific antibody T14 in the fimbria of a non-transgenic mouse 6 months after the injection with the human P301S tau brain extract (left column). Gallyas-Braak-, AT8- and MT1-positive, T14-negative, tau deposits were observed in neurites (arrows) and in oligodendrocytes (arrowheads). No tau pathology was observed in age-matched sham-lesioned animals (right column). The sections were counterstained with haematoxylin. Scale bar, 50 μm (same magnification in all panels).