Table1.

Semi-quantitative grading of filamentous tau pathology in ALZ17 mice injected with brain extract from mice transgenic for human P301S tau (n=5 for each time point).

Anterior (1.7 mm from injection level)
Time	6 months	12 months	15 months
Region
fimbria	++	+++	+++
thalamus	+	++	++
internal capsule	−	+	++
caudate putamen	−	+	+
somatosensory cortex	−	+	+
hypothalamus	−	−	+
amygdala	−	−	+
Injection level
Time	6 months	12 months	15 months
Region
hippocampus *1	++	+++	+++
optic tract	++	++	+++
fimbria	+	++	+++
medial lemniscus	+	++	+++
zona incerta	+	++	+++
thalamus	+	++	++
cerebral peduncle	+	++	++
visual cortex 2	+	+	++
hypothalamus	+	+	+
amygdala	−	+	+
Posterior (1.3 mm from injection level)
Time	6 months	12 months	15 months
Region
cerebral peduncle	++	+++	+++
hippocampus *	+	++	+++
superior colliculus	+	++	++
substantia nigra	+	+	+
entorhinal cortex	−	+	++
deep mesencephalic nucleus	−	+	++
pontine nuclei	−	−	+

−: no Gallyas-Braak-positive structures; +: 0-20; ++: 20-40; +++: >40

^*CA1, CA2, CA3, dentate gyrus and subiculum

¹injection sites

²injection sites