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. 2009 Jun;47(6):1231–1238. doi: 10.1016/j.fct.2009.02.018

Table 1.

Summary of body weight (BW) and weekly body weight grain (BWG) data in the rat subchronic 13-week oral toxicity study.

1 8 15 22 29 36 43 50
Females
Control BW 171.8 ± 5.37 200.6 ± 8.9 219.7 ± 13.34 238.8 ± 15.96 247.2 ± 23.64 257.5 ± 23.03 264.2 ± 20.41 278.1 ± 24.18
BWG 28.8 ± 6.78 19.10 ± 6.54 14.10 ± 7.99 13.40 ± 11.96 10.30 ± 7.41 6.70 ± 7.30 13.90 ± 7.62
100 mg/kg/day BW 172.8 ± 7.77 203.1 ± 7.55 232.2 ± 11.99 234.80 ± 20.95 251.5 ± 21.88 259.1 ± 18.76 271.3 ± 21.26 282.7 ± 26.17
BWG 30.3 ± 8.31 20.10 ± 6.97 11.60 ± 11.57 16.70 ± 9.93 7.60 ± 8.13 12.20 ± 5.45 11.40 ± 8.04
300 mg/kg/day BW 173.2 ± 7.67 205.0 ± 7.96 222.80 ± 5.49 235.6 ± 9.00 252.3 ± 11.2 263.3 ± 10.24 271.3 ± 11.87 281.4 ± 15.78
BWG 31.8 ± 3.71 17.80 ± 10.41 12.80 ± 9.93 16.70 ± 9.32 11.00 ± 6.43 8.00 ± 6.41 10.10 ± 8.91
1000 mg/kg/day BW 172.5 ± 5.40 200.7 ± 10.19 222.50 ± 11.10 238.5 ± 12.15 252.3 ± 17.08 262.3 ± 18.41 273.1 ± 20.06 282.4 ± 20.46
BWG 28.2 ± 7.48 21.80 ± 8.99 16.00 ± 7.27 13.80 ± 9.43 10.00 ± 6.46 10.80 ± 7.51 9.30 ± 9.44



57
 64
 71
 78
 85
 90/91
 Sum (1–91)
Control BW 283.2 ± 27.87 285 ± 26.03 289.2 ± 24.23 296.6 ± 27.02 297.7 ± 30.36 300.5 ± 28.04
BWG 5.10 ± 6.38 1.80 ± 7.50 4.20 ± 8.15 7.40 ± 6.06 1.10 ± 7.03 2.80 ± 5.96 128.70 ± 27.01
100 mg/kg/day BW 287.1 ± 25.92 288 ± 22.2 296 ± 26.09 302.1 ± 29.5 304.1 ± 30.78 307.5 ± 29.26
BWG 4.40 ± 8.45 0.90 ± 6.74 8.00 ± 6.60 6.10 ± 4.86 2.00 ± 7.85 3.40 ± 7.07 134.70 ± 28.88
300vmg/kg/day BW 286.4 ± 18.55 292.3 ± 15.08 295.4 ± 14.72 301.1 ± 16.15 301.7 ± 13.94 306.4 ± 14.71
BWG 5.00 ± 9.02 5.90 ± 7.05 3.10 ± 4.77 5.70 ± 5.12 0.60 ± 6.22 4.70 ± 6.27 133.20 ± 19.36
1000 mg/kg/day BW 288.7 ± 23.76 293.9 ± 21.66 301.9 ± 22.09 306.8 ± 21.80 306.7 ± 26.57 313.2 ± 23.50
BWG 6.30 ± 7.23 5.20 ± 6.09 8.00 ± 4.69 4.90 ± 6.24 −0.10 ± 7.87 6.50 ± 8.50 140.70 ± 23.59



Males 1
 8
 15
 22
 29
 36
 43
 50
Control BW 210.8 ± 6.94 275.1 ± 11.18 329.3 ± 17.93 362.8 ± 21.53 396.7 ± 26.16 424.5 ± 27.00 447.1 ± 31.08 473.2 ± 34.83
BWG 64.30 ± 6.00 54.20 ± 9.35 33.50 ± 8.64 33.90 ± 5.97 27.80 ± 5.09 22.60 ± 4.97 26.10 ± 5.07
100 mg/kg/day BW 211.3 ± 6.02 272.2 ± 12.22 320.6 ± 18.47 354.3 ± 21.38 381.2 ± 24.22 404.3 ± 26.59 424.5 ± 33.60 445.1 ± 35.29⁎
BWG 60.90 ± 7.02 48.40 ± 8.10 33.70 ± 4.69 26.90 ± 5.51⁎⁎ 23.10 ± 3.41⁎ 20.20 ± 8.13 20.60 ± 3.31⁎
300 mg/kg/day BW 211.9 ± 5.32 272.1 ± 6.87 325.4 ± 11.15 362.5 ± 15.79 388.3 ± 17.36 417.9 ± 20.73 439.3 ± 22.21 464.1 ± 24.01
BWG 60.20 ± 3.79 53.30 ± 6.57 37.10 ± 6.28 25.80 ± 5.45⁎⁎ 29.60 ± 5.27 21.40 ± 3.72 24.80 ± 3.55
1000 mg/kg/day BW 210.0 ± 6.55 265.6 ± 10.23 312.6 ± 15.43 344.0 ± 10.32⁎ 369.5 ± 10.56⁎⁎ 393.0 ± 10.17⁎⁎ 411.8 ± 11.29⁎⁎ 431.6 ± 13.83⁎⁎
BWG 55.60 ± 7.17⁎⁎ 47.00 ± 7.13 31.40 ± 8.14 25.50 ± 3.81⁎⁎ 23.50 ± 3.72⁎ 18.80 ± 5.16 19.80 ± 5.81⁎⁎



57
 64
 71
 78
 85
 90/91
 Sum (1–91)
Control BW 482.2 ± 37.05 488.5 ± 36.56 511.2 ± 40.02 527.5 ± 40.76 539.9 ± 42.24 543.9 ± 42.05
BWG 9.00 ± 6.09 6.30 ± 4.11 22.70 ± 7.48 16.30 ± 5.38 12.40 ± 3.66 4.00 ± 4.74 333.10 ± 40.08
100 mg/kg/day BW 457.1 ± 38.79 463.9 ± 39.24 476.1 ± 38.96⁎ 492.6 ± 45.33⁎ 501.7 ± 45.45⁎ 505.4 ± 42.80⁎
BWG 12.00 ± 4.35 6.80 ± 6.30 12.20 ± 5.71⁎⁎ 16.50 ± 7.47 9.10 ± 4.95 3.70 ± 3.89 294.10 ± 39.08
300 mg/kg/day BW 483.2 ± 26.48 493.2 ± 26.74 508.9 ± 27.73 521.0 ± 29.59 534.3 ± 31.93 541.3 ± 35.09
BWG 19.10 ± 4.41⁎⁎ 10.00 ± 4.24 15.70 ± 4.47⁎ 12.10 ± 4.38 13.30 ± 4.55 7.00 ± 4.45 329.40 ± 31.60
1000 mg/kg/day BW 440.3 ± 12.01⁎’ 451.4 ± 13.12⁎⁎ 461.8 ± 15.51⁎⁎ 475.3 ± 20.16⁎⁎ 481.9 ± 19.58⁎⁎ 487.7 ± 21.47⁎⁎
BWG 8.70 ± 2.98 11.10 ± 3.57⁎ 10.40 ± 5.06⁎⁎ 13.50 ± 8.15 6.60 ± 6.60⁎ 5.80 ± 4.24 277.70 ± 21.50

Values are mean ± S.D.

⁎

p < 0.05.

⁎⁎

p < 0.01.