Table 2.

Summary of hematological data in the rat subchronic 13-week oral toxicity study.

Females	RBC (1012/L)	Hgb (g/dL)	Hct (%)	MCV(fL)	MCH (pg)	MCHC (g/dL)	RDW (%)
Control	7.98 ± 0.33	15.03 ± 0.55	41.55 ± 1.57	52.08 ± 1.80	18.81 ± 0.61	36.15 ± 0.65	11.32 ± 0.56
100 mg/kg/day	7.85 ± 0.31	15.02 ± 0.27	4170 ± 068	53.19 ± 2.27	19.18 ± 1.05	36.01 ± 0.75	11.64 ± 0.62
300 mg/kg/day	7.65 ± 0.49	14.53 ± 0.56⁎	40.12 ± 1.60⁎	52.54 ± 2.45	19.04 ± 0.83	36.22 ± 0.71	12.47 ± 2.20
1000 mg/kg/day	7.91 ± 0.53	15.06 ± 0.55	41.38 ± 135	52.42 ± 2.22	19.09 ± 0.88	36.39 ± 0.50	11.52 ± 0.44
Females	PLT (109/L)	MPV (fL)	APTT (s)	PT (s)	Retic. (%)	WBC (1O9/L)
Control	1034.90 ± 92.06	7.74 ± 0.58	18.25 ± 0.79	23.65 ± 1.00	2.22 ± 0.42	1.42 ± 0.32
100 mg/kg/day	1017.70 ± 110.59	7.21 ± 0.38⁎	18.59 ± 0.54	24.06 ± 1.06	2.41 ± 0.43	1.83 ± 0.79
300 mg/kg/day	1023.00 ± 213.31	7.23 ± 0.35⁎	18.39 ± 0.50	24.10 ± 1.28	2.97 ± 2.20	1.68 ± 0.53
1000 mg/kg/day	996.90 ± 161.60	7.26 ± 0.43⁎	18.32 ± 1.05	23.79 ± 0.76	2.26 ± 0.54	2.33 ± 1.60
Males	RBC (1012/L)	Hgb (g/dL)	Hct (%)	MCV (fL)	MCH (pg)	MCHC (g/dL)	RDW (%)
Control	8.69 ± 0.41	15.66 ± 0.61	43.85 ± 1.92	50.46 ± 1.11	18.02 ± 0.37	35.70 ± 0.31	12.51 ± 0.46
100 mg/kg/day	8.60 ± 0.45	15.48 ± 0.58	42.97 ± 1.62	50.01 ± 1.73	18.04 ± 0.69	36.10 ± 0.45	12.06 ± 0.48⁎
300 mg/kg/day	8.56 ± 0.36	15.74 ± 0.74	43.61 ± 2.04	50.97 ± 1.22	18.40 ± 0.48	36.08 ± 0.42	12.46 ± 0.28
1000 mg/kg/day	8.73 ± 0.40	15.53 ± 0.61	43.60 ± 1.64	49.97 ± 1.67	17.80 ± 0.61	35.62 ± 0.58	12.53 ± 0.55
Males	PLT (109/L)	MPV (fL)	APTT (s)	PT (s)	Retic. (%)	WBC (1O9/L)
Control	1030.90 ± 136.70	7.69 ± 0.91	17.65 ± 0.62	25.56 ± 0.89	1.93 ± 0.16	3.40 ± 0.95
100 mg/kg/day	957.20 ± 72.51	7.70 ±0.82	17.61 ± 0.79	25.20 ± 0.89	1.87 ± 0.30	4.01±1.47
300 mg/kg/day	989.00 ± 106.87	7.70 ± 0.48	18.19 ± 0.75	25.48 ± 1.23	2.21 ± 0.21⁎	3.20 ± 1.00
1000 mg/kg/day	1104.30 ± 161.76	7.77 ± 0.61	17.63 ± 1.50	26.53 ± 0.89⁎	1.86 ± 0.30	3.48 ± 1.65

Values are mean ± S.D.

^⁎p < 0.05.