Table 3.

Summary of male serum biochemical data in the rat subchronic 13-week oral toxicity study.

Males	Glucose (mmol/l)	Urea (mmol/l)	Creat. (umol/l)	Na+ (mmol/l)	K+ (mmol/l)	Cl− (mmol/L)	Ca++ (mmol/l)	P (mmol/l)	T. Chol. (mmol/l)
Control	6.94 ± 0.95	6.80 ± 0.94	54.62 ± 6.58	145.61 ± 1.01	5.28 ± 0.49	105.19 ± 1.49	2.47 ± 0.05	2.42 ± 0.25	1.46 ± 0.26
100 mg/kg/day	6.81 ± 1.22	7.67 ± 1.28	58.85 ± 9.79	145.20 ± 0.51	5.06 ± 0.45	104.66 ± 1.45	2.41 ± 0.06⁎	2.39 ± 0.18	1.58 ± 0.15
300 mg/kg/day	6.85 ± 1.44	6.98 ± 0.62	54.69 ± 4.46	144.81 ± 0.71	4.99 ± 0.46	104.7 ± 1.45	2.43 ± 0.06	2.34 ± 0.17	1.60 ± 0.36
1000 mg/kg/day	6.74 ± 0.90	6.81 ± 0.63	54.81 ± 4.13	145.19 ± 1.07	5.35 ± 0.35	104.20 ± 1.16	2.40 ± 0.08⁎	2.360 ± 0.17	1.68 ± 0.28
Males	T. Prot. (g/L)	Alb (g/L)	AST (U/L0)	ALT (U/L)	ALKP (U/L)	GGT (U/L)	T. Bil. (umol/L)	A/G
Control	55.84 ± 1.58	29.79 ± 1.09	119.20 ± 13.74	53.00 ± 4.32	90.90 ± 13.47	6.00 ± 0.00	3.49 ± 0.21	1.16 ± 0.07
100 mg/kg/day	54.69 ± 2.12	28.68 ± 2.09	128.40 ± 19.40	54.60 ± 9.37	87.60 ± 12.57	6.00 ± 0.00	3.04 ± 0.36	1.10 ± 0.08⁎
300 mg/kg/day	53.95 ± 2.02⁎	28.08 ± 1.43⁎	120.70 ± 16.67	54.80 ± 3.29	83.50 ± 11.25	6.00 ± 0.00	3.47 ± 0.63	1.08 ± 0.04⁎
1000 mg/kg/day	55.98 ± 1.69	28.96 ± 0.97	134.70 ± 32.44	55.80 ± 4.18	90.50 ± 16.57	6.00 ± 0.00	3.32 ± 0.72	1.08 ± 0.06⁎

Values are mean ± S.D.

^∗∗p < 0.01.

^⁎p < 0.05.