Table 4.

Summary of female serum biochemical data in the rat subchronic 13-week oral toxicity study.

Females	Glucose (mmol/l)	Urea (mmol/l)	Creat. (umol/l)	Na+ (mmol/l)	K+(mmol/l)	Cl− (mmol/l)	Ca++(mmol/l)	P (mmol/l)	T. Chol. (mmol/l)
Control	6.55 ± 0.86	6.87 ± 0.80	57.83 ± 7.35	144.78 ± 1.29	4.64 ± 0.38	105.05 ± 1.69	2.49 ± 0.10	1.96 ± 0.24	1.83 ± 0.37
100 mg/kg/day	7.44 ± 0.89	7.21 ± 1.73	56.13 ± 7.49	143.79 ± 1.49	4.40 ± 0.44	103.65 ± 2.60	2.43 ± 0.08	1.74 ± 0.39	1.69 ± 0.34
300 mg/kg/day	6.72 ± 0.52	7.06 ± 1.34	53.95 ± 4.10	144.58 ± 1.74	4.40 ± 0.32	105.55 ± 1.33	2.43 ± 0.06	1.85 ± 0.33	1.49 ± 0.26
1000 mg/kg/day	7.06 ± 0.69	7.58 ± 1.16	57.77 ± 7.27	144.85 ± 1.42	4.44 ± 0.37	105.70 ± 1.96	2.43 ± 0.07	2.03 ± 0.25	1.77 ± 0.47
Females	T. Prot. (g/l)	Alb (g/l)	AST (U/L0)	ALT (U/L)	ALKP (U/L)	GGT (U/L)	T. Bil. (Mmol/l)	A/G
Control	54.63 ± 3.50	31.06 ± 3.07	115.50 ± 19.28	46.90 ± 5.82	55.80 ± 11.04	6.00 ± 0.00	4.05 ± 0.66	1.34 ± 0.15
100 mg/kg/day	54.78 ± 2.81	31.02 ± 1.92	120.60 ± 46.93	50.20 ± 11.35	52.80 ± 5.07	6.00 ± 0.00	3.80 ± 0.37	1.31 ± 0.12
300 mg/kg/day	53.60 ± 2.11	28.97 ± 1.95	100.80 ± 17.05	49.80 ± 4.71	56.30 ± 10.56	6.00 ± 0.00	3.55 ± 0.46	1.19 ± 0.10⁎⁎
1000 mg/kg/day	52.80 ± 1.60	28.97 ± 1.23⁎	111.30 ± 22.19	45.50 ± 4.40	57.20 ± 9.04	6.00 ± 0.00	3.47 ± 0.62⁎	1.22 ± 0.06⁎

Values are mean ± S.D.

^⁎p < 0.05.

^⁎⁎p < 0.01.