Table 5.

Summary of mean organ weights (g) and organ weight relative to body weight (%) in the rat subchronic 13-week oral toxicity study.

		Control	100 mg/kg/day	300 mg/kg/day	1000 mg/kg/day
Males
Body weight	g	522.20 ± 38.94	497.00 ± 66.06	523.70 ± 30.98	470.20 ± 20.87⁎⁎
Brain (g)	g	2.23 ± 0.08	2.23 ± 0.14	2.20 ± 0.06	2.14 ± 0.06⁎
	%	0.430 ± 0.036	0.452 ± 0.048	0.422 ± 0.030	0.456 ± 0.024
Liver	g	12.40 ± 1.44	11.29 ± 1.23⁎	12.35 ± 0.93	11.19 ± 0.78⁎
	%	2.371 ± 0.146	2.283 ± 0.193	2.358 ± 0.106	2.379 ± 0.110
Heart	g	1.38 ± 0.16	1.27 ± 0.11	1.35 ± 0.06	1.29 ± 0.09
	%	0.265 ± 0.021	0.258 ± 0.027	0.257 ± 0.013	0.275 ± 0.017
Spleen	g	1.13 ± 0.21	0.97 ± 0.18	1.04 ± 0.11	1.01 ± 0.14
	%	0.216 ± 0.034	0.196 ± 0.024	0.199 ± 0.020	0.215 ± 0.026
Kidneys	g	3.02 ± 0.34	2.81 ± 0.17	2.82 ± 0.20	2.93 ± 0.20
	%	0.576 ± 0.029	0.569 ± 0.051	0.538 ± 0.035⁎	0.623 ± 0.038⁎
Thymus	g	0.45 ± 0.08	0.35 ± 0.11	0.41 ± 0.49	0.36 ± 0.12
	%	0.086 ± 0.014	0.070 ± 0.017	0.078 ± 0.018	0.075 ± 0.024
Testes	g	4.10 ± 0.48	3.68 ± 0.32⁎	3.76 ± 0.21	3.78 ± 0.36
	%	0.786 ± 0.082	0.748 ± 0.086	0.720 ± 0.051	0.805 ± 0.070
Epididymides	g	1.57 ± 0.15	1.46 ± 0.11	1.50 ± 0.18	1.59 ± 0.24
	%	0.301 ± 0.033	0.297 ± 0.038	0.288 ± 0.041	0.337 ± 0.047
Adrenals	g	0.065 ± 0.009	0.061 ± 0.008	0.065 ± 0.011	0.064 ± 0.006
	%	0.0126 ± 0.0021	0.0124 ± 0.0019	0.0125 ± 0.0023	0.0137 ± 0.0013
Females
Body weight	g	284.70 ± 27.35	294.40 ± 28.78	292.60 ± 16.02	296.40 ± 22.97
Brain	g	2.01 ± 0.06	2.03 ± 0.10	1.99 ± 0.09	2.03 ± 0.08
	%	0.711 ± 0.065	0.695 ± 0.065	0.681 ± 0.039	0.688 ± 0.055
Liver	g	6.84 ± 0.91	7.52 ± 0.85	7.36 ± 1.35	7.24 ± 0.73
	%	2.394 ± 0.118	2.556 ± .0209	2.506 ± 0.379	2.441 ± 0.145
Heart	g	0.87 ± 0.08	0.91 ± 0.14	0.88 ± 0.09	0.89 ± 0.06
	%	0.308 ± 0.024	0.310 ± 0.042	0.303 ± 0.032	0.299 ± 0.019
Spleen	g	0.67 ± 0.08	0.75 ± 0.14	0.77 ± 0.17	0.73 ± 0.10
	%	0.236 ± 0.027	0.256 ± 0.048	0.260 ± 0.050	0.246 ± 0.029
Kidneys	g	1.77 ± 0.18	1.85 ± 0.17	1.81 ± 0.16	1.90 ± 0.18
	%	0.623 ± 0.038	0.634 ± 0.077	0.617 ± 0.045	0.639 ± 0.035
Thymus	g	0.27 ± 0.05	0.31 ± 0.06	0.27 ± 0.07	0.32 ± 0.07
	%	0.096 ± 0.018	0.104 ± 0.022	0.092 ± 0.024	0.108 ± 0.021
Uterus	g	0.80 ± 0.23	0.85 ± 0.23	0.78 ± 0.26	0.91 ± 0.34
	%	0.287 ± 0.097	0.294 ± 0.106	0.269 ± 0.094	0.312 ± 0.124
Ovaries	g	0.144 ± 0.030	0.147 ± 0.010	0.147 ± 0.015	0.142 ± 0.030
	%	0.0509 ± 0.0113	0.0505 ± 0.0074	0.0504 ± 0.0065	0.0480 ± 0.0095
Adrenals	g	0.094 ± 0.011	0.094 ± 0.012	0.085 ± 0.011	0.091 ± 0.012
	%	0.0333 ± 0.0041	0.0321 ± 0.0031	0.0289 ± 0.0034⁎	0.0307 ± 0.0039

Values are mean ± S.D.

^⁎p < 0.05.

^⁎⁎p < 0.01.