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A, conformational coupling between the ryanodine receptor (RyR) and canonical transient receptor potential (TRPC) channels. B, conformational coupling between inositol-1,4,5-trisphosphate (IP3) receptors and TRPC channels. C, conformational coupling between ER/SR stromal interaction molecule 1 (STIM1) Ca2+ sensor proteins and Ca2+ permeable Orai1 channels. For clarity, only one Orai1 subunit is shown.
