Figure 2. Uptake (A) and utilisation (B) of triacylglycerol from very-low-density lipoprotein or chylomicrons by isolated working hearts from lean and obese Zucker diabetic fatty (ZDF) rats perfused with TAG-rich lipoproteins.

Isolated rat hearts were perfused with very-low-density lipoprotein (VLDL) or chylomicrons (CM) (0.4 mm TAG) prepared from control or diabetic rats together with [¹⁴C]glucose (11 mm). The concentration of glucose was 11 mm. Triacylglycerol (TAG) uptake was estimated from disappearance of TAG from perfusate. TAG utilisation was calculated as the sum of TAG oxidation and tissue lipid deposition; for further details see text. Results are expressed as means ±s.e.m. (n= 7 per group). Statistically significant differences between diabetic and control hearts are indicated: **P < 0.01; significant differences between diabetic and control lipoproteins are indicated: ^#P < 0.05, ^##P < 0.01; significant differences between VLDL and CM are indicated: ⁺P < 0.05, ⁺⁺P < 0.01; significant differences between diabetic hearts perfused with diabetic lipoproteins and control hearts perfused with control lipoproteins are indicated: ‡P < 0.05.