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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2009 Jun 27;28(5):329–347. doi: 10.1016/j.preteyeres.2009.06.002

Table 2.

Cell Membrane-Bound Molecules that Contribute to Immune Privilege in the Eye.

Molecule
 Effect
 Location
CRP Inhibits complement cascade and inflammation elicited by anaphylatoxins generated during complement activation. Cornea and retina
FasL Induces apoptosis of activated T cells and neutrophils. Cornea, iris, retina
TRAIL Induces apoptosis of macrophages and neutrophils. Cornea, iris, retina
PD-L1 Inhibits T lymphocyte proliferation; induces apoptosis of T lymphocytes. Cornea, iris, retina

CRP = complement regulatory proteins; FasL = CD95L, Fas ligand; TRAIL = tumor necrosis factor-related apoptosis-inducing ligand; PD-L1 = programmed death ligand-1.