Hypothetical model of aedeskinin-III signaling to the paracellular pathway
in Malpighian tubules of the yellow-fever mosquito. The paracellular protein
complex consists of cytoplasmic elements such as the cytoskeleton, scaffolding
and regulatory proteins, and integral membrane proteins reaching into the
paracellular space. The proteins defining the paracellular
barrier/permeability properties are unknown in insect epithelia. ADF, actin
depolymerizing factor; GPCR, G-protein-coupled receptor;
α,β,γ, subunits of G protein; GTP, guanosine triphosphate;
PLC, phospholipase C; PIP2, phosphatidylinositol
(4,5)-bisphosphate; DAG, diacylglycerol; PKC, protein kinase C; SERCA,
sarcoplasmic and endoplasmic reticulum calcium ATPase.