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. Author manuscript; available in PMC: 2009 Aug 14.
Published in final edited form as: Mol Ther. 2008 May 6;16(8):1481–1489. doi: 10.1038/mt.2008.92

Figure 1. Predicted secondary structure of anti-gp120 aptamer–small interfering RNA (siRNA) chimeras.

Figure 1

The region of anti-gp120 aptamer responsible for binding to gp120 is outlined in green. The siRNA part of the chimera consists of 27 base pairs as an example here, targeting Site-I of human immunodeficiency type 1 tat/rev. Two mutated chimeras, M-1 (mutant aptamer) and M-2 (mutant siRNA), were constructed as experimental controls. Mutated regions are shown in magenta.