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. Author manuscript; available in PMC: 2010 Aug 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2009 May 23;239(1):71–79. doi: 10.1016/j.taap.2009.05.017

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Superoxide dismutase 1 (SOD-1) and proteasome activity in brain, spinal cord and sciatic nerve of controls and rats exposed to N,N-diethyldithiocarbamate (DEDC) for 8 weeks. (A) SOD-1 activity determined as units/mg protein based upon the autoxidation of 5,6,6a,11b-tetrahydro-3,9,10 trihydroxybenzo[c]fluorine following inactivation of SOD-2 (see Materials and Methods for details) (*p < 0.05 and **p < 0.01 relative to control by unpaired one-tailed student's t-test n = 5 for controls and n = 6 for DEDC exposed). (B) Proteasome activity determined from the generation of free amino-4-methylcoumarin (AMC) from an LLVY-AMC substrate. No significant differences were detected.