APPENDIX TABLE 1.

Unadjusted associations between maternal alcohol consumption during the first trimester and isolated and nonisolated infant clefts, Norway, 1996–2001

Maternal alcohol consumption in the first trimester	Cleft lip with or without cleft palate				Cleft palate only
	Isolated (n = 314)		Nonisolated (n = 63)		Isolated (n = 118)		Nonisolated (n = 78)
	OR*	95% CI*	OR	95% CI	OR	95% CI	OR	95% CI
Total no. of drinks
None	1.0	Referent	1.0	Referent	1.0	Referent	1.0	Referent
1–3	1.3	0.9, 1.9	1.3	0.7, 2.6	1.1	0.6, 1.9	1.7	0.9, 3.0
4–6	1.5	0.8, 2.5	1.7	0.6, 4.5	2.0	1.0, 4.0	1.7	0.7, 4.3
≥7	1.5	1.0, 2.4	1.4	0.6, 3.2	1.5	0.8, 2.7	1.3	0.6, 3.0
No. of drinking days
None	1.0	Referent	1.0	Referent	1.0	Referent	1.0	Referent
1–2	1.4	1.1, 2.0	1.5	0.8, 2.7	1.2	0.8, 1.9	1.8	1.1, 3.0
3–6	1.9	1.1, 3.4	1.4	0.4, 4.6	2.6	1.3, 5.4	1.1	0.3, 3.9
≥7	1.0	0.6, 1.9	1.0	0.3, 3.3	0.9	0.3, 2.2	0.8	0.2, 2.7
Average no. of drinks per sitting
None	1.0	Referent	1.0	Referent	1.0	Referent	1.0	Referent
1	1.2	0.9, 1.8	0.8	0.3, 1.7	1.4	0.8, 2.2	1.5	0.9, 2.8
2–4	1.3	0.9, 2.0	2.2	1.1, 4.2	1.2	0.7, 2.3	1.3	0.6, 2.7
≥5	2.4	1.3, 4.4	2.3	0.7, 6.8	1.8	0.7, 4.5	2.9	1.1, 7.4
Average no. of drinks per sitting/no. of drinking days
None	1.0	Referent	1.0	Referent	1.0	Referent	1.0	Referent
1–4 drinks/1–2 days	1.3	0.9, 1.8	1.5	0.5, 4.4	1.2	0.7, 1.9	1.8	1.0, 3.0
1–4 drinks/≥3 days	1.2	0.8, 1.9	0.8	0.1, 5.4	1.7	0.9, 3.1	0.7	0.2, 2.2
≥5 drinks/1–2 days	2.1	1.0, 4.4	1.6	0.3, 21.0	2.1	0.8, 5.8	2.7	0.9, 8.3
≥5 drinks/≥3 days	3.1	1.1, 8.8	3.9	0.8, 19.2	1.0	0.1, 8.4	3.3	0.7, 16.2

^*OR, odds ratio; CI, confidence interval.