APPENDIX TABLE 1.
Maternal alcohol consumption in the first trimester | Cleft lip with or without cleft palate |
Cleft palate only |
||||||
Isolated (n = 314) |
Nonisolated (n = 63) |
Isolated (n = 118) |
Nonisolated (n = 78) |
|||||
OR* | 95% CI* | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
Total no. of drinks | ||||||||
None | 1.0 | Referent | 1.0 | Referent | 1.0 | Referent | 1.0 | Referent |
1–3 | 1.3 | 0.9, 1.9 | 1.3 | 0.7, 2.6 | 1.1 | 0.6, 1.9 | 1.7 | 0.9, 3.0 |
4–6 | 1.5 | 0.8, 2.5 | 1.7 | 0.6, 4.5 | 2.0 | 1.0, 4.0 | 1.7 | 0.7, 4.3 |
≥7 | 1.5 | 1.0, 2.4 | 1.4 | 0.6, 3.2 | 1.5 | 0.8, 2.7 | 1.3 | 0.6, 3.0 |
No. of drinking days | ||||||||
None | 1.0 | Referent | 1.0 | Referent | 1.0 | Referent | 1.0 | Referent |
1–2 | 1.4 | 1.1, 2.0 | 1.5 | 0.8, 2.7 | 1.2 | 0.8, 1.9 | 1.8 | 1.1, 3.0 |
3–6 | 1.9 | 1.1, 3.4 | 1.4 | 0.4, 4.6 | 2.6 | 1.3, 5.4 | 1.1 | 0.3, 3.9 |
≥7 | 1.0 | 0.6, 1.9 | 1.0 | 0.3, 3.3 | 0.9 | 0.3, 2.2 | 0.8 | 0.2, 2.7 |
Average no. of drinks per sitting | ||||||||
None | 1.0 | Referent | 1.0 | Referent | 1.0 | Referent | 1.0 | Referent |
1 | 1.2 | 0.9, 1.8 | 0.8 | 0.3, 1.7 | 1.4 | 0.8, 2.2 | 1.5 | 0.9, 2.8 |
2–4 | 1.3 | 0.9, 2.0 | 2.2 | 1.1, 4.2 | 1.2 | 0.7, 2.3 | 1.3 | 0.6, 2.7 |
≥5 | 2.4 | 1.3, 4.4 | 2.3 | 0.7, 6.8 | 1.8 | 0.7, 4.5 | 2.9 | 1.1, 7.4 |
Average no. of drinks per sitting/no. of drinking days | ||||||||
None | 1.0 | Referent | 1.0 | Referent | 1.0 | Referent | 1.0 | Referent |
1–4 drinks/1–2 days | 1.3 | 0.9, 1.8 | 1.5 | 0.5, 4.4 | 1.2 | 0.7, 1.9 | 1.8 | 1.0, 3.0 |
1–4 drinks/≥3 days | 1.2 | 0.8, 1.9 | 0.8 | 0.1, 5.4 | 1.7 | 0.9, 3.1 | 0.7 | 0.2, 2.2 |
≥5 drinks/1–2 days | 2.1 | 1.0, 4.4 | 1.6 | 0.3, 21.0 | 2.1 | 0.8, 5.8 | 2.7 | 0.9, 8.3 |
≥5 drinks/≥3 days | 3.1 | 1.1, 8.8 | 3.9 | 0.8, 19.2 | 1.0 | 0.1, 8.4 | 3.3 | 0.7, 16.2 |
OR, odds ratio; CI, confidence interval.