Table 3.
Adjusted Odds Ratiosa and 95% Confidence Intervals for Any, Nonadvanced, and Advanced Metachronous Colorectal Neoplasia According to Body Mass Index Categories in the Pooled Population, by Family History
| BMI Category | No Family History of Colorectal Cancerb (n = 5,807) |
|||||||||||
| Any |
Nonadvanced |
Advanced |
||||||||||
| Odds Ratio | 95% Confidence Interval | Recurrence, no. | Total, no. | Odds Ratio | 95% Confidence Interval | Recurrence, no. | Total, no. | Odds Ratio | 95% Confidence Interval | Recurrence, no. | Total, no. | |
| Total population | ||||||||||||
| Normal weight (BMI, <25) | 1.00 | 747 | 1,658 | 1.00 | 548 | 1,658 | 1.00 | 199 | 1,658 | |||
| Overweight (BMI, 25–<30) | 1.08 | 0.95, 1.22 | 1,265 | 2,633 | 1.09 | 0.95, 1.25 | 946 | 2,633 | 1.02 | 0.83, 1.25 | 319 | 2,633 |
| Obese (BMI, ≥30) | 1.25 | 1.08, 1.45 | 758 | 1,516 | 1.26 | 1.08, 1.47 | 569 | 1,516 | 1.25 | 0.99, 1.57 | 189 | 1,516 |
| Ptrend | <0.01 | <0.01 | <0.06 | |||||||||
| Men | ||||||||||||
| Normal weight (BMI, <25) | 1.00 | 507 | 1,029 | 1.00 | 378 | 1,029 | 1.00 | 129 | 1,029 | |||
| Overweight (BMI, 25–<30) | 1.08 | 0.93, 1.26 | 1,045 | 2,082 | 1.06 | 0.90, 1.25 | 777 | 2,082 | 1.11 | 0.87, 1.41 | 268 | 2,082 |
| Obese (BMI, ≥30) | 1.31 | 1.10, 1.55 | 612 | 1,147 | 1.27 | 1.06, 1.53 | 457 | 1,147 | 1.43 | 1.09, 1.87 | 155 | 1,147 |
| Ptrend | <0.01 | <0.01 | <0.01 | |||||||||
| Women | ||||||||||||
| Normal weight (BMI, <25) | 1.00 | 240 | 629 | 1.00 | 170 | 629 | 1.00 | 70 | 629 | |||
| Overweight (BMI, 25–<30) | 1.09 | 0.86, 1.38 | 220 | 551 | 1.17 | 0.90, 1.52 | 169 | 551 | 0.87 | 0.59, 1.30 | 51 | |
| Obese (BMI, ≥30) | 1.11 | 0.85, 1.44 | 146 | 369 | 1.18 | 0.88, 1.59 | 112 | 369 | 0.91 | 0.58, 1.42 | 34 | 369 |
| Ptrend | <0.43 | <0.22 | <0.60 | |||||||||
| Family History of Colorectal Cancerb (n = 1,876) | ||||||||||||
| Any | Nonadvanced | Advanced | ||||||||||
| Odds Ratio |
95% Confidence Interval |
Recurrence, no. |
Total, no. |
Odds Ratio |
95% Confidence Interval |
Recurrence, no. |
Total, no. |
Odds Ratio |
95% Confidence Interval |
Recurrence, no. |
Total, no. |
|
| Total population | ||||||||||||
| Normal weight (BMI, <25) | 1.00 | 225 | 519 | 1.00 | 155 | 519 | 1.00 | 70 | 519 | |||
| Overweight (BMI, 25–<30) | 1.28 | 1.02, 1.61 | 470 | 902 | 1.41 | 1.10, 1.80 | 358 | 902 | 0.99 | 0.70, 1.40 | 112 | 902 |
| Obese (BMI, ≥30) | 1.45 | 1.12, 1.88 | 245 | 455 | 1.62 | 1.22, 2.14 | 188 | 455 | 1.11 | 0.74, 1.66 | 57 | 455 |
| Ptrend | <0.01 | <0.001 | <0.62 | |||||||||
| Men | ||||||||||||
| Normal weight (BMI, <25) | 1.00 | 122 | 244 | 1.00 | 88 | 244 | 1.00 | 34 | 244 | |||
| Overweight (BMI, 25–<30) | 1.21 | 0.90, 1.63 | 349 | 653 | 1.25 | 0.90, 1.72 | 265 | 653 | 1.05 | 0.67, 1.66 | 84 | 653 |
| Obese (BMI, ≥30) | 1.71 | 1.20, 2.43 | 184 | 299 | 1.75 | 1.21, 2.54 | 141 | 299 | 1.47 | 0.87, 2.50 | 43 | 299 |
| Ptrend | <0.01 | <0.01 | <0.15 | |||||||||
| Women | ||||||||||||
| Normal weight (BMI, <25) | 1.00 | 103 | 275 | 1.00 | 67 | 275 | 1.00 | 36 | 275 | |||
| Overweight (BMI, 25–<30) | 1.15 | 1.06, 2.15 | 121 | 249 | 1.77 | 1.19, 2.62 | 93 | 249 | 1.01 | 0.58, 1.74 | 28 | 249 |
| Obese (BMI, ≥30) | 1.11 | 0.74, 1.67 | 61 | 156 | 1.31 | 0.83, 2.06 | 47 | 156 | 0.74 | 0.37, 1.44 | 14 | 156 |
| Ptrend | <0.38 | <0.12 | <0.43 | |||||||||
Abbreviation: BMI, body mass index.
a
Models adjusted for age, sex, smoking, and study.
b
Data for family history of colorectal cancer in 1 or more first-degree relatives were missing for 530 participants as follows: normal weight (n = 155), overweight (n = 236), and obese (n = 139); normal weight men (n = 100), overweight men (n = 187), and obese men (n = 101); and normal weight women (n = 55), overweight women (n = 49), and obese women (n = 38).