Table 4.

Adjusted Odds Ratios^a and 95% Confidence Intervals for Distal or Proximal Metachronous Colorectal Neoplasia According to Category of Body Mass Index

BMI Category	Distalb				Proximalc
	Odds Ratio	95% Confidence Interval	Recurrence, no.	Total, no.	Odds Ratio	95% Confidence Interval	Recurrence, no.	Total, no.
Total populationd
Normal weight (BMI, <25)	1.00		204	1,498	1.00		461	1,755
Overweight (BMI, 25–<30)	1.06	0.88, 1.29	335	2,262	1.16	1.02, 1.33	861	2,788
Obese (BMI, ≥30)	1.02	0.81, 1.27	164	1,209	1.34	1.15, 1.57	506	1,551
Ptrend	<0.85				<0.001
Mene
Normal weight (BMI, <25)	1.00		131	828	1.00		293	990
Overweight (BMI, 25–<30)	0.95	0.75, 1.19	252	1,693	1.17	0.99, 1.38	696	2,137
Obese (BMI, ≥30)	1.03	0.80, 1.35	128	832	1.42	1.17, 1.71	393	1,097
Ptrend	<0.40				<0.001
Womene
Normal weight (BMI, <25)	1.00		73	670	1.00		168	765
Overweight (BMI, 25–<30)	1.40	1.00, 1.96	83	569	1.17	0.91, 1.50	165	651
Obese (BMI, ≥30)	0.89	0.58, 1.35	36	377	1.19	0.90, 1.56	113	454
Ptrend	<0.92				<0.19

Abbreviation: BMI, body mass index.

^aModels adjusted for age, sex, smoking, and study.

^bDescending colon, sigmoid colon, or rectum.

^cAscending colon, hepatic flexure, transverse colon, or splenic flexure.

^dParticipants with only distal or only proximal neoplasia included and compared with those with no metachronous lesions; those with both types were excluded as follows: normal weight (n = 373), overweight (n = 648), and obese (n = 395); normal weight men (n = 252), overweight men (n = 533), and obese men (n = 322); and normal weight women (n = 121), overweight women (n = 115), and obese women (n = 73).

^eP_interaction = 0.72 and 0.31 for body mass index by sex for distal neoplasia and for proximal neoplasia, respectively.