Table 5.
Odds Ratios and 95% Confidence Intervals for the Association Between a GSTP1 Exon 5 (Ile105Val, 313A → 313G) Polymorphism (Ile/Val and Val/Val vs. Ile/Ile) and Lung Cancer in the Pooled Analysis, Stratified by Histologic Type and Ethnicity
| Ethnic Group | Unadjusted | Adjusteda | ||||||
| No. of Cases | No. of Controls | OR | 95% CI | No. of Cases | No. of Controls | OR | 95% CI | |
| White | ||||||||
| Adenocarcinoma | 1,048 | 4,098 | 1.08 | 0.95, 1.24 | 1,043 | 4,077 | 1.041 | 0.90, 1.21 |
| Squamous cell carcinoma | 1,394 | 4,098 | 1.00 | 0.86, 1.09 | 1,377 | 4,077 | 0.994 | 0.87, 1.14 |
| Small cell carcinoma | 399 | 4,098 | 1.11 | 0.90, 1.36 | 393 | 4,077 | 1.103 | 0.91, 1.41 |
| Asian | ||||||||
| Adenocarcinoma | 384 | 768 | 1.32 | 1.02, 1.70 | 384 | 768 | 1.33 | 1.02, 1.74 |
| Squamous cell carcinoma | 206 | 768 | 1.44 | 1.05, 1.98 | 206 | 768 | 1.36 | 0.95, 1.94 |
| Small cell carcinoma | 5 | 768 | 0.50 | 0.06, 4.52 | 5 | 768 | 0.44 | 0.04, 4.56 |
| Total | ||||||||
| Adenocarcinoma | 1,496 | 5,032 | 1.05 | 0.94, 1.18 | 1,491 | 5,009 | 1.11 | 0.98, 1.26 |
| Squamous cell carcinoma | 1,617 | 5,032 | 1.02 | 0.91, 1.14 | 1,600 | 5,009 | 1.03 | 0.91, 1.16 |
| Small cell carcinoma | 412 | 5,032 | 1.22 | 1.00, 1.49 | 406 | 5,009 | 1.12 | 0.90, 1.39 |
Abbreviations: CI, confidence interval; GSTP1, glutathione S-transferase pi gene; Ile, isoleucine; OR, odds ratio; Val, valine.
a
Adjusted for study ID (an assigned study identifier for each study population), sex, smoking (ever/never), and age.