Table 3.

Age-adjusted Stroke Rates per 100,000, by Various Stroke Measures, Among Men Aged 30–74 Years in the Minneapolis-St. Paul, Minnesota, Metropolitan Area From 1980 to 2000

Stroke Measurea	1980		1985		1990		1995		2000		P-Trend
	Rate	95% CI	Rate	95% CI	Rate	95% CI	Rate	95% CI	Rate	95% CI
Definition 1	307	272, 345	245b	215, 278	242	214, 273	231	205, 260	199c	182, 216	<0.0001
Definition 2	177	150, 206	168	143, 195	158	135, 183	154	132, 177	121	108, 134	<0.0001
Definition 3	170	144, 198	160	136, 187	166	143, 192	149	127, 172	124d	111, 138	<0.0001
Definition 4	116	95, 140	108	88, 130	96	78, 115	101	84, 120	91	80, 103	<0.0001
Definition 5					120	101, 142	103	85, 122	116	102, 129	NS
Ischemic					102	84, 122	82	66, 99	94	82, 106	NS
Hemorrhagic					18	11, 28	21	14, 30	22	17, 28
Definition 3 incident events			115	95, 137	120	100, 142	106	88, 126	91	80, 103	<0.0001
Definition 4 incident events			77	60, 95	68	53, 85	74	59, 90	68	58, 78	0.02

Abbreviations: CI, confidence interval; NS, not significant.

^aDefinition 1: International Classification of Diseases, Ninth Revision (ICD-9) codes 431, 432, 434, 436, 437; definition 2: first-position ICD-9 codes 431, 432, 434, 436, 437; definition 3: World Health Organization stroke; definition 4: Minnesota Stroke Survey stroke; definition 5: neuroimaging stroke. Refer to the Materials and Methods section of the text for stroke measure definitions.

^bP = 0.0003 for comparison between 1985 and 1980.

^cP = 0.02 for comparison between 2000 and 1995.

^dP = 0.03 for comparison between 2000 and 1995.