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. 2009 Apr 2;169(11):1378–1387. doi: 10.1093/aje/kwp062

Table 4.

Use of Nonaspirin NSAIDs and Acetaminophen and Incidence of Ovarian Cancer in the Nurses’ Health Study (1990–2004) and Nurses’ Health Study-II (1989–2005)

Nonaspirin NSAIDs
 Acetaminophen
Cases, no.a Hazard Ratiob 95% Confidence Intervalb Hazard Ratioc 95% Confidence Intervalc Cases, no.a Hazard Ratiob 95% Confidence Intervalb Hazard Ratioc 95% Confidence Intervalc
Use ≥2 times/week
    Never 267 1.00 1.00 295 1.00 1.00
    Past 75 1.13 0.87, 1.48 1.12 0.86, 1.47 54 0.98 0.72, 1.32 0.98 0.73, 1.33
    Current 119 0.81 0.65, 1.02 0.81 0.64, 1.01 112 1.15 0.92, 1.43 1.14 0.92, 1.43
No. of days/weekd
    <2 341 1.00 1.00 360 1.00 1.00
    2–4 34 0.80 0.56, 1.14 0.80 0.56, 1.14 26 0.88 0.59, 1.31 0.87 0.58, 1.30
    ≥5 26 0.90 0.60, 1.35 0.88 0.59, 1.32 18 1.15 0.71, 1.85 1.13 0.70, 1.82
        Ptrende 0.71 0.64 0.64 0.70
Duration of regular use, year(s)f
    <1 280 1.00 1.00 312 1.00 1.00
    1–<2 61 1.17 0.88, 1.55 1.17 0.88, 1.56 56 1.20 0.87, 1.66 1.19 0.86, 1.65
    2–<5 64 1.03 0.78, 1.36 1.02 0.77, 1.35 54 0.97 0.66, 1.42 0.96 0.65, 1.40
    ≥5 56 0.93 0.68, 1.26 0.92 0.67, 1.25 39 0.88 0.56, 1.38 0.86 0.55, 1.37
        Ptrende 0.58 0.53 0.83 0.83

Abbreviation: NSAID, nonsteroidal antiinflammatory drug.

a

Numbers may not add up to the total number of cases because of missing information on exposure.

b

Models stratified jointly by age in months and by 2-year time cycles.

c

Models stratified jointly by age in months and by 2-year time cycles and additionally adjusted for duration of oral contraceptive use, parity, tubal ligation, menopausal status, and current postmenopausal hormone use.

d

Cumulative average days per week; information available from 1990 to 2004 (Nurses’ Health Study) and from 1995 to 2005 (Nurses’ Health Study-II).

e

P values (Wald statistics) modeling categories of use linearly and continuous measures of frequency (days/week) and duration (years).

f

Duration of regular use since 1990 (Nurses’ Health Study)/1989 (Nurses’ Health Study-II); information available from 1990 to 2004 (Nurses’ Health Study) and from 1989 to 2005 (Nurses’ Health Study-II).