Table 5.
Use of Any NSAIDs (Aspirin and Nonaspirin) and Incidence of Borderline Ovarian Tumors in the Nurses’ Health Study (1990–2004) and Nurses’ Health Study-II (1989–2005)
| Cases, no.a | Hazard Ratiob | 95% Confidence Intervalb | Hazard Ratioc | 95% Confidence Intervalc | |
| Use ≥2 times/week | |||||
| No | 27 | 1.00 | 1.00 | ||
| Past | 13 | 1.00 | 0.50, 2.00 | 0.95 | 0.48, 1.91 |
| Yes | 22 | 0.60 | 0.33, 1.10 | 0.58 | 0.32, 1.06 |
| No. of days/weekd | |||||
| <2 | 43 | 1.00 | 1.00 | ||
| 2–3 | 8 | 0.55 | 0.26, 1.17 | 0.55 | 0.25, 1.17 |
| ≥4 | 2 | 0.24 | 0.06, 1.01 | 0.24 | 0.06, 0.98 |
| Ptrende | 0.01 | 0.01 | |||
| Duration of regular use, year(s)f | |||||
| <1 | 28 | 1.00 | 1.00 | ||
| 1–<2 | 11 | 1.39 | 0.67, 2.86 | 1.36 | 0.66, 2.81 |
| ≥2 | 21 | 0.50 | 0.27, 0.91 | 0.47 | 0.26, 0.87 |
| Ptrende | 0.04 | 0.03 | |||
Abbreviation: NSAID, nonsteroidal antiinflammatory drug.
Numbers may not add up to the total number of borderline cases because of missing information on exposures.
Models jointly stratified on age (months) and 2-year time cycles.
Models jointly stratified on age (months) and 2-year time cycles and adjusted for duration of oral contraceptive use, parity, tubal ligation, menopausal status, and postmenopausal hormone use.
Cumulative average number of days per week; information available from 1990 to 2004 (Nurses’ Health Study) and from 1995 to 2005 (Nurses’ Health Study-II).
P value (Wald statistics) modeling continuous measure of frequency (days per week) and duration (years).
Duration of regular use since 1990 (Nurses’ Health Study)/1989 (Nurses’ Health Study-II).