TABLE 1.

Incidence of human herpesvirus 8 infection per 100 child-years and associated hazard rate ratios in a longitudinal cohort study of 684 children, by maternal and child characteristics, Lusaka, Zambia, 1998–2004

Characteristic	No. of children	%	No. of HHV-8*-positive children	No. of HHV-8-free child-years	Incidence rate per 100 child-years	Unadjusted HRR*	95% CI*	Adjusted HRR	95% CI
Total cohort	684		212	1,532.1	13.8
Sex of child
Male	349	51	101	799.3	12.6	0.84	0.64, 1.10	0.84†	0.64, 1.10
Female	335	49	111	732.8	15.2	1.00‡		1.00‡
Mother's HIV-1* status at delivery
Uninfected	533	78	140	1,194.7	11.7	1.00‡		1.00‡
Infected	151	22	72	337.5	21.3	1.79	1.35, 2.38	1.16†	0.82, 1.63
Mother's HHV-8 status at delivery
Negative	314	46	104	672.5	15.5	1.00‡		1.00‡
Positive	370	54	108	859.7	12.6	0.82	0.62, 1.07	0.84†	0.64, 1.10
Mother's HIV-1 and HHV-8 status§
HIV-1− and HHV-8−	240	35	63	511.8	12.3	1.00‡		1.00‡
HIV-1− and HHV-8+	293	43	77	682.9	11.3	0.92	0.66, 1.29	0.91¶	0.65, 1.26
HIV-1+ and HHV-8−	74	11	41	160.7	25.5	2.05	1.38, 3.03	1.29¶	0.83, 2.02
HIV-1+ and HHV-8+	77	11	31	176.8	17.5	1.40	0.91, 2.15	0.94¶	0.59, 1.49
Child's HIV-1 status at age 24 months
Uninfected	643	94	178	1,478.1	12.0	1.00‡		1.00‡
Infected	41	6	34	54.0	63.0	5.17	3.55, 7.52	4.60†	2.93, 7.22

^*HHV-8, human herpesvirus 8; HRR, hazard rate ratio; CI, confidence interval; HIV-1, human immunodeficiency virus type 1.

^†Adjusted for sex of the child, mother's HHV-8 status, mother's HIV-1 status, and child's HIV-1 status at age 24 months.

^‡Reference category.

^§A positive sign (+) indicates seropositivity and a negative sign (−) indicates seronegativity.

^¶Adjusted for sex of the child and child's HIV-1 status at age 24 months.