Table 2.

Odds Ratios for the Association Between Use of Nonsteroidal Antiinflammatory Drugs and Distal Large Bowel Cancer, North Carolina Colon Cancer Study II, 2001–2006

	Cases		Controls		ORa	95% CI	Multivariable ORb	95% CI
	No.	%	No.	%
Never use (referent)	248	24.3	169	17.0	1.00		1.00
Ever use	772	75.7	827	83.0	0.67	0.54, 0.84	0.66	0.52, 0.83
Recent usec	688	67.5	775	77.8	0.64	0.51, 0.80	0.62	0.49, 0.79
Average monthly use in the past 5 years, no. of times
<15	446	43.7	415	41.7	0.73	0.57, 0.92	0.68	0.53, 0.88
≥15	326	32.0	412	41.4	0.61	0.48, 0.79	0.62	0.48, 0.81
Regular used of NSAIDs, by type
Over-the-counter aspirin	355	34.8	439	44.1	0.62	0.49, 0.80	0.62	0.48, 0.80
Over-the-counter nonaspirin NSAIDs	119	11.7	110	11.0	0.77	0.56, 1.08	0.72	0.51, 1.02
Prescription nonselective NSAIDs	66	6.5	81	8.1	0.59	0.40, 0.87	0.57	0.38, 0.85
Selective COX-2 inhibitors	87	8.5	135	13.6	0.48	0.34, 0.68	0.44	0.31, 0.63

Abbreviations: CI, confidence interval; COX-2, cyclooxygenase 2; NSAIDs, nonsteroidal antiinflammatory drugs; OR, odds ratio.

^aAdjusted for age (continuous), sex, race (African-American or White), and sampling probability.

^bAdjusted for age (continuous), sex, race (African-American or White), sampling probability, body mass index (weight (kg)/height (m)²; <25, 25–29.9, or ≥30) 1 year prior, ever use of calcium supplements in the past 5 years, physical activity 1 year prior (<1,882, 1,882–2,077, or ≥2,078 metabolic equivalent-minutes/day), total energy intake (<1,711, 1,711–2,413, or ≥2,414 kcal/day), and dietary fat intake (<64, 64–97, or ≥98 g/day).

^cContinuing use in the year before diagnosis/interview.

^dUse at least 3 times per week for 3 months or more.