Fig. 4.

Estimated spline transformation and confidence interval for the relationship of increasing plasma ADPN levels with cardiovascular and mortality outcomes, while controlling for covariates (the covariates shown to be significant in the adjusted models for each outcome in Table 3) showing that the relationship between increasing levels of ADPN and outcomes is non-linear. The spline reflects only the non-linearity and not the actual magnitude of the association for increasing ADPN levels scaled per SD.