Table 4.
Time-dependent Cox regression for the relationship of ADPN levels measured over time with mortality and cardiovascular outcomes. Multiple measurements of plasma CRP and IL-6 at the same time points were available and included in the model as time-dependent covariates. The final multivariable models were arrived at by backward selection
| Outcome variable | All-cause mortality and cardiovascular events | |||||
|---|---|---|---|---|---|---|
| Unadjusted | Final model adjusted for covariates | |||||
| Predictor variable | HR | 95% CI | P | HR | 95% CI | P |
| ADPN levels (per μg/mL)a | 1.01 | 0.99–1.03 | 0.12 | |||
| ADPN levels (per μg/mL)b | 0.87 | 0.67–1.15 | 0.33 | 0.73 | 0.55–0.98 | 0.03 |
| ADPN * ADPNb | 1.02 | 1.00–1.05 | 0.11 | 1.04 | 1.01–1.07 | <0.01 |
| Age (per year) | 1.03 | 1.01–1.05 | <0.01 | 1.04 | 1.02–1.06 | <0.01 |
| Sex (versus male) | 0.95 | 0.68–1.33 | 0.75 | |||
| Race (versus AA) | 1.53 | 1.09–2.15 | 0.01 | |||
| Duration on HD (years) (per log) | 1.10 | 0.95–1.26 | 0.21 | 1.31 | 1.11–1.55 | <0.01 |
| BMI (per log) | 0.99 | 0.63–2.28 | 0.97 | |||
| Diabetes | 0.97 | 0.69–1.36 | 0.85 | |||
| Smoking (versus never) | 1.52 | 1.08–2.13 | 0.02 | 1.69 | 1.16–2.47 | <0.01 |
| Vascular disease | 1.61 | 1.11–2.33 | 0.01 | |||
| Serum albumin (per g/dL) | 0.98 | 0.61–1.59 | 0.94 | |||
| Serum CRP levels (mg/dL) (per log)c | 1.19 | 1.04–1.36 | 0.01 | |||
| Serum IL-6 levels (pg/mL) (per log)c | 1.21 | 1.03–1.41 | 0.02 | |||
| Kt/V group (high versus standard) | 1.22 | 0.87–1.71 | 0.25 | |||
| Flux group (high versus low) | 0.70 | 0.50–0.98 | 0.04 | 0.53 | 0.36–0.78 | <0.01 |
aADPN shown as a linear term—without transformation of the variable.
bADPN shown as a quadratic term, with concomitant adjustment for the linear term.
cSeparate models were constructed with either CRP or IL-6 included. Except for their respective coefficients, estimates for other covariates were similar.