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Effect of pioglitazone on the expression of the fibrotic factor PAI-1 in the kidney of the Zucker fa/fa rat. Representative pictures of tissue sections immunostained for PAI-1. Magnification: ×400. Top panels: PGT, pioglitazone; LZR, lean Zucker rats, untreated. OZR: obese Zucker rats, untreated for the indicated time periods. Bottom panels: OZR-PGT, OZR treated with pioglitazone for the indicated time periods and doses.
