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Effect of pioglitazone on blood glucose levels, creatinine clearance and proteinuria, throughout treatment in the ZDF fa/fa rat. Values were obtained at the indicated periods. Solid circles: LZR, untreated; solid squares: ZDFR, untreated; blank circles: ZDFR treated with pioglitazone (low dose, long-term). *P < 0.05 for LZR versus other groups; †P < 0.05 for untreated ZDFR versus other groups.
