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. 2009 Feb;13(1):43–61. doi: 10.1089/omi.2009.0011

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Copyright 2009, Mary Ann Liebert, Inc.

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FIG. 4. — Frequency histograms of the stable warfarin weekly dose required to achieve an international normalized ratio of prothrombin time (INR) within the optimal target range (2–3.5) in Brazilian patients with cardiovascular disease. The VKORC1 3673G>A polymorphism (rs9923231) was used to stratify the study sample into three genotypic groups. The histogram presents the variability in warfarin dose in the three VKORC1 genotypes: GG (N = 170), GA (N = 180), and AA (N = 40). Data are expressed as percent of the individuals with different warfarin dose requirements in each genotypic group. Note the marked overlap in distribution of warfarin dose among the three VKORC1 genotypes.