FIG. 5.—

Maximum likelihood phylograms depicting relationships among adult β-like globin genes based on 0.8 kb of 5′ flanking sequence, 5,028 bp of intron 2, and 1 kb of 3′ flanking sequence. The analysis included data from two afrotherians (African elephant, Loxodonta africana, and the lesser hedgehog tenrec, Echinops telfairi), two xenarthrans (nine-banded armadillo, Dasypus novemcinctus, and Hoffmann's two-toed sloth, Choloepus didactylus), two representative boreoeutherian species (human, Homo sapiens, and European rabbit, Oryctalagus cuniculus), and two marsupial species (the gray short-tailed opossum, Monodelphis domestica, and the North American opossum, Didelphis virginiana). All HBB and HBD sequences were retrieved from full genomic contigs (see text for details). The 5′ flanking sequence of the elephant HBBps pseudogene was not included in the analysis due to missing data (i.e., the upstream region, together with exon 1, intron 1, and part of exon 2 was deleted in the Loxodonta genome; see fig. 3). Because the β-like globin genes of mammals have undergone multiple rounds of duplication that have resulted in tandemly repeated sets of paralogous gene copies, we index each paralog with the symbol—T followed by a number that corresponds to the linkage order in the 5′ to 3′ orientation (Aguileta et al. 2006).