Table 2.

Selection Test on Candidate Svs Genes from the Screen

Gene	Mouse–Rat dN/dSa	Species in Divergent Analysisb	Ratio of dN/dS (%Codons)c	P Value: All Speciesd	Codon Sites under Selectione
Svs3	0.55	2, 3, 4, 6, 7, 9	1.0 (41)	0.99	None
Svs5	1.47	1, 3, 5, 8, 9	4.85 (1.3)	0.87	None
Svs6	0.83	2, 3, 4, 6, 7, 8, 9	1.0 (0)	1.0	None
Svs7	1.74	1, 2, 3, 5, 6, 7, 8, 9	12.38 (33)	<0.0001	11S, 14K, 16R, 23S, 24Q, 25S, 28V, 31P, 40H, 42V, 44T, 50K, 52M, 54S, 64T, 66K, 67K, 75E
Primate Svs7		10, 11, 12, 13, 14	10.74 (19)	0.0047	8Y, 18R, 38D, 52R, 59R, 60G, 75V

^a Mouse–Rat d_N/d_S was determined using the evolutionary screen.

^b The genomes/species used in this analysis are 1) mouse genome (C57BL/6), 2) Mus musculus domesticus, 3) Mus musculus musculus, 4) Mus musculus castaneus, 5) Mus spicilegus, 6) Mus spretus, 7) Mus caroli, 8) Mus pahari, 9) rat genome (Rattus norvegicus), 10) human genome (Homo sapiens), 11) rhesus macaque genome (Macaca mulatta), 12) orangutan genome (Pongo pygmaeus), 13) marmoset genome (Callithrix jacchus), and 14: tarsier genome (Tarsius syrichta).

^c The d_N/d_S ratio of the class of codons under positive selection is given with the percentage of codon sites predicted to be in that class.

^d The P value rejecting the model of neutral evolution (M8A) over that of selection (M8) is given.

^e Sites with posterior probabilities greater than 0.9 are indicated in regular typeface; P > 0.95 indicated in bold typeface; and P > 0.99 indicated in bold, underlined typeface.