Fig. 4.

Characteristics of α-syn aggregates and inclusions in the brains of AD patients. a Representative section from the brain of an AD patient immunostained with an antibody against the NAC region of α-syn. The staining shows characteristic plaques composed of Aβ protein. b Representative section from the brain of an AD patient immunostained with an antibody against α-syn that detected Lewy body-like inclusions in the neocortex. c Representative section from the brain of an AD patient double immunolabeled with antibodies against Aβ and α-syn shows co-localization of the two signals in plaques. Scale bar, 20 μm (a), 10 μm (b, c)