Fig. 5.

Molecular dynamics of α-syn and Aβ interactions leading to the formation of hybrid pores in the membrane. a Conformation of α-syn dimer in the presence of one molecule of Aβ. b Conformation of α-syn trimer with the Aβ monomer. c Conformation of α-syn pentamer with the Aβ monomer and the formation of a central pore-like channel. d Space-filled model showing the pore-like α-syn pentamer with the Aβ monomer embedded in a membrane