Figure 2.

Orchestration of higher-order chromatin dynamics during the cell cycle. Several crucial processes are regulated through the formation of factories/bodies such as transcription, Polycomb, insulator or SATB1 bodies/factories in the G1 phase, or replication, repair or recombination factories during the S phase. Their assembly/disassembly must be coordinated in a timely manner during the cell cycle, possibly involving common partners (perhaps cohesin) or mechanisms (such as DNA looping) that are also involved in the higher-order organization of chromosomes during G2/M phases. SATB1, special AT-rich sequence-binding protein 1.