Skip to main content
. 2009 Aug 21;5(8):e1000474. doi: 10.1371/journal.pcbi.1000474

Table 3. Links between selected metabolic reactions and top ranked drug classes.

Rank Thymidylate Synthetase (TS) Reaction E-value
1 Thymidylate synthase inhibitor (TS) 2.54E-75
2 Glycinamide ribonucleotide formyltransferase inhibitor (GART) 4.76E-73
3 Thymidine kinase inhibitor (TK) 1.18E-62
4 Dihydrofolate reductase inhibitor (DHFR) 1.91E-48
5 Folylpolyglutamate synthetase inhibitor 2.27E-31
6 Nucleoside reverse transcriptase inhibitor (NRTI) 5.68E-11
Rank Dihydrofolate Reductase (DHFR) Reaction E-value
1 Glycinamide Ribonucleotide Formyltransferase Inhibitor 1.02E-134
2 Thymidylate Synthetase Inhibitor 1.96E-123
3 Dihydrofolate Reductase Inhibitor 1.46E-82
4 Folylpolyglutamate Synthetase Inhibitor 3.15E-62