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. 2009 Feb 11;136(6):897–903. doi: 10.1242/dev.027979

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Fig. 3. — Molar teeth of K5-Cre/polaris^flox/flox mice and Wnt1-Cre/polaris^flox/flox mice. (A,B) There are no supernumerary teeth in K5Cre (A) and K5-Cre/polaris^flox/flox (B) mice. (C) Sagittal sections showing first molar (m1) and second molar (m2) in mandible. (D) Supernumerary teeth (sn) were observed in Wnt1-Cre/polaris^flox/flox mice. (E-F′) Radioactive in situ hybridisation on sagittal sections showing Gli1 (E,F) and Shh (E',F') expression in mandibles of embryo heads. (E,F) Yellow circles represent positions of Shh expression in adjacent sections (blue arrowheads in E',F'). Gli1 expression (E,F) was expanded into the diastema of Wnt1-Cre/Polaris^flox/flox mice (green arrowheads). Images show lower mandibles of E11.5 (E-F'), newborn (C,D) and adult (A,B).