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. Author manuscript; available in PMC: 2010 Aug 15.
Published in final edited form as: Cancer Res. 2009 Jul 28;69(16):6454–6462. doi: 10.1158/0008-5472.CAN-08-4896

Figure 6. Model of the role of heat-induced NPM-DNA association in increased radiation sensitivity.

Figure 6

(A) Illustration of the MAR region in an unheated cell with a radiation induced strand break that inhibits the rewinding of the right DNA loop. (B) Illustration of the MAR region in a heated cell with a radiation induced strand break that is buried in a protein-DNA aggregate and cannot inhibit the rewinding of the right DNA loop. (C) The downstream effects of the heat-induced masking of DNA damage which include inhibition of repair and increased radiation induced cell killing. Note that the 6-10 Kb range beyond the MAR is suggested by previous studies.