Table 1.
Demographic and Course of Illness Characteristics
| Alcohol Dependence Family History | ||||
|---|---|---|---|---|
| Total | Positive | Negative | p | |
| (n=12) | (n=11) | |||
| N (%) | ||||
| Education (College Graduate) | 14 (64) | 9 (75) | 5 (50) | 0.22 |
| Sex (Male) | 14 (61) | 8 (67) | 6 (55) | 0.55 |
| MDD: Family History | 18 (78) | 9 (75) | 9 (82) | 0.69 |
| Alcohol Abuse/Dependence: Self-History | 8 (35) | 4 (33) | 4 (36) | 0.88 |
| Childhood Abuse | ||||
| • Physical | 9 (39) | 6 (50) | 3 (30) | 0.34 |
| • Sexual | 3 (13) | 2 (17) | 1 (10) | 0.65 |
| • Physical and/or Sexual | 10 (44) | 6 (50) | 4 (40) | 0.69 |
| Mean (SD) | ||||
| Age | 43.5 (14.1) | 47.4 (15.0) | 39.2 (12.2) | 0.17 |
| Age of Onset | 19.8 (9.9) | 20.9 (10.8) | 18.6 (9.3) | 0.59 |
| Duration of Illness (Years) | 23.7 (12.5) | 26.5 (14.3) | 20.6 (10.0) | 0.26 |
| Duration of Episode (Months) | 82.1 (103.5) | 88.3 (122.8) | 75.4 (83.0) | 0.77 |
| Clinical Measures | ||||
| • MADRS | 32.8 (4.3) | 30.8 (2.6) | 34.9 (4.8) | 0.02 |
| • HDRS | 20.2 (4.3) | 17.9 (2.7) | 22.6 (4.5) | 0.01 |
| • BDI | 26.8 (7.9) | 26.5 (8.5) | 27.1 (7.6) | 0.86 |
| • BPRS | 36.0 (6.1) | 33.6 (4.4) | 38.7 (6.8) | 0.04 |
| • BPRS Dysphoric | 19.6 (3.6) | 18.1 (3.1) | 21.2 (3.6) | 0.04 |
| • BPRS Negative | 6.7 (3.3) | 5.5 (2.0) | 8.0 (4.0) | 0.07 |
| • BPRS Positive | 4.1 (0.3) | 4.2 (0.4) | 4.1 (0.3) | 0.61 |
| • CADSS | 5.4 (9.7) | 3.7 (5.2) | 7.3 (13.0) | 0.39 |
| N (%) | ||||
| • Response (MADRS: 50% Decrease) | 10 (43) | 8 (67) | 2 (18) | 0.02 |
| • Remission (MADRS < 10) | 6 (26) | 5 (42) | 1 (9) | 0.08 |
Abbreviations: BDI: Beck Depression Inventory; BPRS: Brief Psychiatric Rating Scale; MADRS: Montgomery-Asberg Depression Rating Scale; HDRS: Hamilton Depression Rating Scale, CADSS: Clinician Administered Dissociative States Scale.