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. 2009 Aug 4;4(8):e6494. doi: 10.1371/journal.pone.0006494

Table 1. Summary of immunological and physiological genes of interest with significant differences in expression between control and infected frogs.

Function Tissue Time-Point Average Fold Change JGI Gene ID Ensembl Gene ID
Coagulation factor liver early −4 279909, 293803, 330213, 341521, 341530, 341561 ENSXETG00000002964, ENSXETG00000002769
Coagulation factor liver late −5 147254, 279909, 292258, 292259, 293803, 330213, 341521, 341530, 341561 ENSXETG00000002964, ENSXETG00000002769, ENSXETG00000003472, ENSXETG00000025492, ENSXETG00000025493
Complement component (alternative pathway) liver early −6 308546, 327877, 420558 ENSXETG00000005261, ENSXETG00000010935, ENSXETG00000024110
Complement component (membrane attack complex) liver early −6 282192, 295244 ENSXETG00000003532, ENSXETG00000006766
Complement component (classical pathway) liver early −3 399987, 471107 ENSXETG00000005203, ENSXETG00000027636
Complement component (classical pathway) liver late −2 399976, 399987,400010, 420551 ENSXETG00000010930, ENSXETG00000023914, ENSXETG00000027636
Cytochrome Cyp450 liver early −3 113474, 297805, 325065, 448177, 464259 ENSXETG00000005868, ENSXETG00000006924, ENSXETG00000013846, ENSXETG00000016349, ENSXETG00000024804, ENSXETG00000027605
Cytochrome Cyp450 liver late −4 >50 genes, see Table S1 >50 genes, see Table S1
Epoxide hydrolase liver late −4 126998, 152658, 398826 ENSXETG00000017581, ENSXETG00000022654, ENSXETG00000028064
Heat shock protein 70 liver late 4 268191, 287936, 361977, 456096 ENSXETG00000006714, ENSXETG00000008828, ENSXETG00000010075, ENSXETG00000016838
Heat shock protein 70 skin late 6 361977, 456096 ENSXETG00000006714, ENSXETG00000008828
Keratin, type I skin late 10 178963 ENSXETG00000012482
NF-kappa inhibitor liver late 3 309572, 396637, 309732 ENSXETG00000006998, ENSXETG00000012114
Ornithine decarboxylase skin late 18 196068, 284956, 295202 ENSXETG00000003519, ENSXETG00000007373
Small chemokine, interleukin 8 liver late −3 295905 NA

Because multiple genes with similar function were often perturbed, fold change is given as an average for all differentially expressed genes in each category. Genes with increased and decreased expression in Bd-exposed frogs show positive and negative fold changes, respectively. See text for additional genes of interest and Table S1 for a complete gene list of differentially expressed genes.