Table 1. Proportion of carriers of CHEK2*1100delC in women with bilateral breast cancer by number of affected first-degree relatives and by age group.
| United Kingdom |
Finland |
the Netherlands |
Russia |
Germany |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BBC |
ICR_FBC |
Pooled OR |
HEBCS |
Rotterdam |
ABCS |
Pooled OR |
St. Petersburg |
GENICA/SKK |
||||
| n/N (%) | n/N (%) | OR (95% CI) | n/N (%) | OR (95% CI) | n/N (%) | n/N (%) | OR (95% CI) | n/N (%) | OR (95% CI) | n/N (%) | OR (95% CI) | |
| Controls | 4/637 (0.63) | 6/1,027 (0.58) | 1.00 (Ref) | 26/1,885 (1.38) | 1.00 (Ref) | 9/909 (0.99) | 1.00 (Ref) | 1/821 (0.12) | 1.00 (Ref) | 6/1,251 (0.48) | 1.00 (Ref) | |
| All bilaterals | 11/583 (1.89) | 10/321 (3.12) | 3.93 (1.76-9.39) | 10/144 (6.94) | 5.34 (2.2-11.7) | 15/144 (10.42) | 15/247 (6.07) | 8.31 (3.79-20.1) | 8/145 (5.16) | 47.88 (6.30-2,126.8) | 2/106 (1.87) | 3.99 (0.4-22.6) |
| Family history | ||||||||||||
| Bilaterals 0 FDR | 4/400 (1.00) | 1/96 (1.04) | 1.68 (0.45-5.44) | 2/55 (3.64) | 2.70 (0.30-11.3) | 7/59 (11.86) | 10/109 (9.17) | 11.26 (4.63-29.1) | 8/114 (7.02) | 47.81 (9.30-464.3) | N/K | — |
| Bilaterals 1 FDR | 5/158 (3.16) | 3/153 (1.96) | 4.37 (1.48-12.4) | 7/78 (8.97) | 7.05 (2.49-17.4) | 5/58 (8.62) | 1/53 (1.89) | 5.71 (1.63-18.3) | 0/28 (0) | — | N/K | — |
| Bilaterals 2+ FDR | 2/25 (8.00) | 6/72 (8.33) | 10.91 (3.17-33.9) | 1/11 (9.09) | 7.15 (0.16-53.5) | 3/27 (11.11) | 0/19 (0) | 6.98 (1.17-29.2) | — | — | N/K | — |
| Age at first diagnosis | ||||||||||||
| Bilaterals <40 | 3/99 (3.03) | 3/68 (4.41) | 6.28 (1.85-19.3) | 0/12 (0) | 0 | 4/40 (10.00) | 5/91 (5.49) | 9.38 (3.20-27.2) | 2/25 (8.00) | 55.09 (3.8-774.5) | 0/6 (0) | 0 |
| Bilaterals 40-49 | 4/233 (1.72) | 5/124 (4.03) | 4.28 (1.52-11.8) | 4/37 (10.81) | 8.67 (2.1-27.0) | 4/59 (6.78) | 10/151 (6.62) | 7.14 (2.83-18.9) | 1/52 (1.92) | 12.42 (0.2-240.8) | 1/20 (5.00) | 10.92 (0.23-96.5) |
| Bilaterals 50+ | 4/250 (1.60) | 2/129 (1.55) | 2.66 (0.79-8.13) | 6/95 (6.32) | 4.82 (1.58-12.4) | 7/44 (15.91) | 0/5 (0) | 16.67 (4.97-52.6) | 5/63 (7.94) | 70.69 (7.63->3,000) | 1/80 (1.25) | 2.62 (0.06-22.0) |
NOTE: Data from the HBBCS are included in pooled analyses of all studies and tests of heterogeneity between studies but are not included in this table as there were no carriers among 138 cases. There were 113, 21, and 3 cases with 0, 1, and 2 affected first-degree relatives, respectively, with missing information for 1 case. There were 13, 29, 46, and 50 cases age <40, 40-49, 50-59, and 60+, respectively. There was missing information on family history ABCS (n = 66), St. Petersburg (n = 3), and missing age information on age at diagnosis BBC (n = 1), Rotterdam (n = 1), St. Petersburg (n = 5). Abbreviation: N/K, not known; FDR, first-degree relatives.