Skip to main content
. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Neuropsychopharmacology. 2008 Oct 15;34(6):1467–1481. doi: 10.1038/npp.2008.183

Figure 1.

Figure 1

Chronic treatment with protriptyline (10, 20 mg/kg) for 2 weeks reduced norepinephrine transporter (NET) expression, determined by 3H-nisoxetine binding (a) and SDS–PAGE/immunoblotting (b), and reduced immobility time in the forced-swim test (c). All measures were determined 2 days after the end of the chronic treatment period, except one group (10 mg/kg per day with 1 day washout). Data shown are means ± SEM of 5–8 rats per group. *p < 0.05, ***p < 0.001 vs control.