Table 1.

Hazard ratios and 95% confidence intervals relating quartiles ofenergy-adjusted total folate intake to incident Alzheimer'sDisease. Model 1 is adjusted for age and gender. Model 2 isadjusted also for ethnic group, education, and APOE-ε4 allele, history of diabetes, hypertension, current smoking, heartdisease, stroke, and intake of vitamins B6 and B12.

Folate quartiles (μg)	At risk	Cases (Rate per 100 person-years)	Model 1	Model 2
1 (≤ 292.9)	241	54 (3.7)	1.0	1.0
2 (293.0 - 365.0)	241	52 (3.4)	1.1 (0.7, 1.6)	0.9 (0.6,1.3)
3 (365.1 – 487.8)	241	49 (3.2)	0.9 (0.6,1.3)	0.7 (0.5,1.1)
4 (≥ 487.9)	242	37 (2.6)	0.7 (0.5,1.1)	0.5 (0.3,0.9)
P for trend			0.13	0.02