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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Lancet Neurol. 2009 May;8(5):491–500. doi: 10.1016/S1474-4422(09)70061-4

Figure 1. Neurogenesis in the SVZ of the lateral ventricle of adult rodent non-ischaemic and ischaemic brain tissue.

Figure 1

A and B show sagittal and coronal views, respectively, of rat brain tissue in the SVZ. SVZ cells in the non-ischaemic brain are proliferating, as shown by BrdU-positive cells (C, arrows, brown dots). After stroke, the number of these proliferating cells increased (D, brown). Confocal microscopic images (E and F) show that BrdU-positive cells (green) are positive for doublecortin (red), indicating that these are newly generated neuroblasts. G to I show doublecortin-positive cells (red) in the ischaemic (G and H) and non-ischaemic (I) hemispheres of rats treated with erythropoietin (G) and saline (H and I). Treatment of erythropoietin substantially increased doublecortin-positive cells in the SVZ and ischaemic striatum (G). Bars are 50 μm (D), 20 μm (E), and 10 μm (F). BrdU=5-bromo-2′-deoxyuridine. CC=corpus callosum. DG=dentate gyrus. EPO=erythropoietin. LV=lateral ventricle. OB=olfactory bulb. RMS=rostral migratory stream. Str=striatum. SVZ=subventricular zone.