Fig. 5.

Light micrographs of the position corresponding to the maturation stage of amelogenesis in AMBN^Δ5–6 mice incisors. (A) In the absence of full-length AMBN, the enamel organ is disorganized, and mineralized masses (arrowhead) of variable appearance gradually appear within it. In some cases, connective tissue (CT) forms between the enamel organ and dentin, and there is a metachromatic interfacial line (black arrow) between it and the material overlying the dentin (inset). (B) In AMBN^Δ5–6 mice, the enamel organ is generally directly in contact with the dysplastic mineralized matrix (white arrow) that forms on the dentin surface.