Figure 3.
Annualized change in estimated glomerular filtration rate (mL/min/1.73 m2/year ± SD) in patients treated with agalsidase-alfa at 0.2 mg/kg every 2 weeks (left bars) followed by weekly treatment (right bars). Patients are stratified by baseline proteinuria: <0.3 g/day, black bars; >1 g/day, open bars. Adapted with permission from Schiffmann R, Askari H, Timmons M, et al 2007. Weekly enzyme replacement therapy may slow decline of renal function in Fabry patients who are on long-term biweekly dosing. J Am Soc Nephrol, 18:1576–83. Copyright © 2007 American Society of Nephrology.