Table 2.
Ten most significant allelic combinations differing in carriage between responders and nonresponders, their carriage rates among responders and nonresponders and the exact Fisher’s and permutation test p-values.
| SNP1 | SNP2 | SNP3 | SNP4 | Carriage in | Fisher’s p-value |
Odds ratio (95% CI) |
Permutation p-value |
|
|---|---|---|---|---|---|---|---|---|
| R (%) | NR (%) | |||||||
| JAK2 rs1887429*T | IL10RB rs2834167*G | GBP1 rs12089335*T | PIAS1 rs10162905*A | 4.8 | 20.7 | 0.00019 | 0.2 (0.1–0.5) | 0.0008 |
| JAK2 rs1887429*T | IL10RB rs2834167*G | GBP1 rs10493822*G | 6.3 | 21.1 | 0.0008 | 0.2 (0.1–0.6) | 0.0018 | |
| JAK2 rs1887429*T | IL10RB rs2834167*G | GBP1 rs12089335*T | 6.2 | 20.7 | 0.0009 | 0.3 (0.1–0.6) | 0.0019 | |
| JAK2 rs1887429*G | IL10 rs1800872*A | CASP3 rs2019978*G | 13.9 | 1.1 | 0.0004 | 14.3 (1.9–109.1) | 0.0012 | |
| JAK1 rs310249*G | PNPT1 rs782584*C | TYK2 rs2304256*C | 5.3 | 20.7 | 0.0007 | 0.2 (0.1–0.5) | 0.0017 | |
| JAK1 rs310249*G | PNPT1 rs782584*C | LEP rs7799039*G | 5.3 | 20.7 | 0.0007 | 0.2 (0.1–0.5) | 0.0017 | |
| JAK1 rs310249*G | PNPT1 rs782584*C | CASP7 rs12415607*C | 6.2 | 22.0 | 0.0008 | 0.2 (0.1–0.6) | 0.0018 | |
| JAK1 rs310249*G | PNPT1 rs782584*C | PRKR rs2270414*T | 3.8 | 17.1 | 0.0013 | 0.2 (0.1-.06) | 0.0023 | |
| JAK1 rs310249*G | IFNAR2 rs8127890*A | LEP rs7799039*A | 1.5 | 12.5 | 0.0009 | 0.1 (0.02–00.5) | 0.0019 | |
| TYK2 rs280501*C | DUSP1 rs881150*T | PRKCA rs3764402*A | 90.7 | 73.1 | 0.0012 | 3.6 (1.6–8.0) | 0.0023 | |
NR: Nonresponder; R: Responder