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. Author manuscript; available in PMC: 2009 Aug 17.
Published in final edited form as: Mol Cell. 2004 Dec 22;16(6):907–917. doi: 10.1016/j.molcel.2004.11.037

Figure 3.

Figure 3

Analysis of the AF2, Helix H12, Conformation in CAR/Androstenol

(A) Crystal packing of the CAR/androstenol complex. In one CAR molecule (purple), helix H12 is exposed to solvent channels within the crystal. Symmetry partners are shown in green and cyan.

(B) Helix H12 of the second molecule (purple) is stabilized through crystal contacts with a neighboring molecule (blue) through a Gly354-Lys187 hydrogen bond. The arrow indicates missing density.

(C) Model of CAR (purple) superimposed on the PPARα/SMRT complex (cyan/red) indicates that predicted SMRT/CAR interactions are retained, particularly from the CAR Lys187. The residues in parentheses are from PPARα.