Table 1. Some Parasite Strains Commonly Used for Compound Screening.
| Target Pathogens | Parasite Strains | Drug Sensitivity Phenotype |
| Chagas disease | ||
| Trypanosoma cruzi | Tulahuen LacZ, Clone C4a (same as Tulahuen ß-gal; Tulahuen CL2; Tulahuen C4 LacZ; MHOM/CL/100/Tulahuen) | Sensitive to benznidazole, nifurtimox |
| HAT | ||
| Trypanosoma brucei brucei | Squib427 ( = STIB795)a | Sensitive to suramin; reference drugs: melarsoprol, pentamidine |
| STIB950b | Sensitive to melarsoprol, pentamidine and suramin; resistant to diminazene, isometamidium and quinapyramine | |
| GUTat3.1b | Sensitive to suramin; reference drugs: melarsoprol, pentamidine | |
| STIB345a | Sensitive to diminazene aceturate | |
| Trypanosoma brucei gambiense | STIB754/130Ra | Sensitive to melarsoprol, pentamidine and suramin |
| STIB930b | Sensitive to melarsoprol, pentamidine and suramin | |
| Trypanosoma brucei rhodesiense | STIB900a | Sensitive to melarsoprol, pentamidine and suramin |
| Trypanosoma congolense | STIB910 ( = STIB249)b | Sensitive to melarsoprol, pentamidine and suramin |
| Leishmaniasis | ||
| Leishmania donovani | MHOM-ET-67/L82a (same as MHOM/ET/67/HU3; LV9) | Sensitive to sodium stibogluconate and miltefosine |
| Leishmania infantum | MHOM/MA(BE)/67a | Sensitive to sodium stibogluconate and miltefosine |
| Leishmania major | MHOM/SA/85/JISH118a | Reference drug: sodium stibogluconate |
| MHOM/SU/59/NEAL-P | Reference drug: sodium stibogluconate | |
| Leishmania mexicana | MHOM/BZ/82/Bel21c | Reference drug: pentamidine |
| Leishmania panamensis | MHOM/PA/67/Boyntonc | Reference drug: meglumine antimonate |
| Malaria | ||
| Plasmodium falciparum | NF54b | Sensitive to all known antimalarials |
| 3D7 (derived from NF54)b | Sensitive to all known antimalarials | |
| K1b | Sensitive to mefloquine; resistant to chloroquine and pyrimethamine | |
| GHAb | Sensitive to chloroquine | |
| T23b | Resistant to chloroquine and pyrimethamine | |
| D6b | Sensitive to chloroquine, pyrimethamine, sulfadoxine and quinine; less sensitive to mefloquine | |
| W2b | Sensitive to mefloquine; less sensitive to chloroquine; resistant to quinine, pyrimethamine and sulphadoxine | |
| TM91C235b | Multidrug resistant | |
| RCSb | Multidrug resistant | |
| FCR3b | Sensitive to pyrimethamine; resistant to chloroquine and cycloguanil | |
| TM90C2bb | Less sensitive to mefloquine, resistant to chloroquine and atovaquone | |
| WR87 (wild type)b | Not known | |
| KN27b | Not known | |
| Plasmodium berghei | ANKAc | Sensitive to chloroquine and artemisinin |
| Nc | Sensitive to chloroquine | |
| Plasmodium yoelii | NSc | Resistant to chloroquine |
| Plasmodium chabaudi | ASc | Resistant to pyrimethamine |
| Plasmodium vinckei | Not knownc | Sensitive to chloroquine |
| Lymphatic filariasis | ||
| Brugia malayi | Indiaa | Reference drug: diethylcarbamazine |
| Brugia pahangi | Not known | Reference drug: diethylcarbamazine |
| Onchocerciasis | ||
| Onchocerca gutturosa | Ghanaa | Reference drugs: amocarzine, ivermectin and melarsomine dihydrochloride |
| Onchocerca lienalis | UKa | Reference drugs: amocarzine, ivermectin and melarsomine dihydrochloride |
| Onchocerca ochengi | Cameroonb | Reference drugs: amocarzine, ivermectin and melarsomine dihydrochloride |
| Schistosomiasis | ||
| Schistosoma mansoni | Puerto Ricana | Reference drug: praziquantel |
| Egyptian Sambona | Reference drug: praziquantel | |
| Schistosoma haematobium | Egyptiana | Reference drug: praziquantel |
a
Used for both vitro screens and vivo rodent models.
b
Used for vitro screens.
c
Used for vivo rodent models.