TABLE 1.
Comparison of systemic parameters in the three study groups: B-ND, STZ-MH, and STZ-D rats.
| Group | Rats | Days Diabetic | Weight (g) | Blood Glucose before urethane (mg/dl) | Blood Glucose after urethane (mg/dl) | Arterial Hematocrit at start of Experiment (%) | Arterial Hematocrit at end of experiment (%) | Arterial Blood Pressure during measurements (mm Hg) |
|---|---|---|---|---|---|---|---|---|
| B-ND | 5 | 0 | 402 ± 43 (356-451) | 86.4 ± 8.6b (74-95) | 175.8 ± 59.8 (132-279) | 49.8 ± 2.5 (45.5-52.0) | 46.9 ± 3.9 (41.8-50.8) | 86.6 ± 11.7 (70-101) |
| STZ-MH | 4 | < 1 week | 394 ± 28 (355-418) | 142.5 ± 44.4a (93-192) | 245.0 ± 48.2 (200-296) | 48.9 ± 2.2 (47.3-52.0) | 48.3 ± 2.3 (46.0-51.3) | 81.8 ± 5.3 (77-90) |
| STZ-D | 7 | 64 ± 4 (59-71) | 293 ± 36a,b (240-345) | 435.4 ± 29.3a,b (389-473) | 466.8 ± 30.1a,b (429-497) | 46.4 ± 2.9 (42.8-50.0) | 45.4 ± 3.2 (38.8-49.0) | 85.5 ± 7.1 (79-95) |
| ANOVA p-value | <0.001 | <0.001 | <0.001 | 0.111 | 0.370 | 0.754 | ||
All values are means ± SD. Values in parentheses represent ranges. The p-value reports the significance of the one-way ANOVA test to compare the values among the three groups. The Bonferroni t-test was used to compare the multiple pairs among the three groups if the ANOVA test showed a significant difference.
a
p<0.05 compared to B-ND group
b
p<0.05 compared to STZ-MH group