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. Author manuscript; available in PMC: 2009 Aug 17.
Published in final edited form as: Neurosci Biobehav Rev. 2008 Aug 22;33(5):690–698. doi: 10.1016/j.neubiorev.2008.08.008

Figure 2.

Figure 2

This hypothetical model graphically represents the concept that poor response inhibition, mediated by genetically-determined alterations in forebrain catecholamine transmission, is a risk factor for both ADHD and substance abuse. The abuse of illicit substances is also an environmental risk factor that produces further adaptations in catecholamine systems, leading to increasing impairments in response inhibition.